A Novel Pkhd1 Mutation Interacts with the Nonobese Diabetic Genetic Background To Cause Autoimmune Cholangitis

Susceptibility Region on Chromosome 1 in Nonobese Diabetic Mice: A Major Genetic Analysis of Autoimmune Sialadenitis

Spontaneous Autoimmune Diabetes in Monoclonal T Cell Nonobese Diabetic Mice

It has been established that insulin-dependent diabetes mellitus (IDDM) in nonobese diabetic (NOD) mice results from a CD4+ and CD8+ T cell-dependent autoimmune process directed against the pancreatic beta cells. The precise roles that beta cell-reactive CD8+ and CD4+ T cells play in the disease process, however, remain ill defined. Here we have investigated whether naive beta cell-specific CD8...

Insensitivity to pain due to Genetic Mutation

Pain is neuroanatomically, psychologically and neurophysiologically complicated and its first function is protecting all alive creature body. This issue is so questionable and interesting that people who don’t feel pain how face this sensation and what problems threaten them. So many researchers by using 73 references, articles from electronical and library references have done a clinical...

A Novel Approach to Background Subtraction Using Visual Saliency Map

Generally human vision system searches for salient regions and movements in video scenes to lessen the search space and effort. Using visual saliency map for modelling gives important information for understanding in many applications. In this paper we present a simple method with low computation load using visual saliency map for background subtraction in video stream. The proposed technique i...

Autoimmune cholangitis – a clinical case

The authors present the case of a previously healthy, asymptomatic 45 year old female patient, who was referred to the Internal Medicine service for study of elevated hepatic enzyme levels (alkaline phosphatase, gamma-glutamyl transferase and amino transferases) diagnosed in routine laboratory tests. The patient did not present any alterations in the objective examination and further study reve...